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Asymptomatic
Intensive Care
?

- This web-based tool has been developed based on the publication from Beksac et al in order to calculate the probability of intensive care unit (ICU) admission or asymptomatic presentation. To be able to calculate the risk; age, blood type, number of comorbidities and Killer-immunoglobulin-like Receptor (KIR) genotypes are required. KIR haplotypes are described in Figure 1.

Description of the Model:

* Prediction Model Formula: exp(-3.52 + 1.56 Age Group - 2.74 Blood group (type-A vs others) + 1.26 number of comorbidities - 2.46 tAB1 with ligand + 3.17 tAA with ligand)
* Correct Classification Rate for Asymptomatic (specificity): 92.9%
* Correct Classification Rate for Critical Care (sensitivity): 76%

Reference:

  • Beksac M, Akin HY, Gencer-Oncul EB, Yousefzadeh M, Cengiz Seval G, Gulten E, Akdemir Kalkan I, Cinar G, Memikoglu O, Karaagaoglu E, Dalva K. A model integrating Killer Immunoglobulin-like Receptor (KIR) haplotypes for risk prediction of COVID-19 clinical disease severity. Immunogenetics. 2021 Sep 18. doi: 10.1007/s00251-021-01227-4. Epub ahead of print. PMID: 34536086.




    • * Please choose the appropriate number according to how many of the following comorbidities you have.
    - Diabetes Mellitus
    - Obesity
    - Hypertension
    - Chronic Obstructive Pulmonary Disease (COPD)
    - Coronary Artery Disease
    - Chronic Kidney Disease (CKD)
    - Cancer




    Figure 1. Representative illustration of distribution of KIR genes (w binding ligands) within KIR haplotypes, based on both the content of A/B haplotypes and their chromosomal locations (telomeric or centromeric). Grey boxes represent framework genes. Blue and orange boxes show inhibitory and activating KIR receptors (iKIR and aKIR) and purple boxes represents the HLA ligands binding specifically with their corresponding receptors.